| Southern Tier Independence Center | Not-for-profit, community-based advocacy and service organization for children and adults with all types of disabilities. |
| Southern Vermont Therapeutic Riding Center | Enrich, educate, and expand the lives of individuals with special needs through equine-assisted activities and therapies. |
| Southwest Center for Independence (SWCI) | People with disabilities providing supports and training for the disability and elder communities to live well in southwest Colorado. |
| Southwest Idaho Area Agency on Aging | Provides solutions for seniors, people with disabilities and caregivers aimed at securing safe, healthy, community supported and independent living options. |
| Southwest Kansas Area Agency on Aging | To promote the well being of older Kansans and individuals with disabilities in Southwest Kansas. |
| Southwest LA Independence Center | Assists persons with significant disabilities in achieving and maintaining self-sufficient, productive lives. |
| Southwest LA Independence Center – Leesville | Assists persons with significant disabilities in achieving and maintaining self-sufficient, productive lives. |
| Southwest LA Independent Center – Lafayette | Assists persons with significant disabilities in achieving and maintaining self-sufficient, productive lives. |
| Southwest Tennessee AAAD | The primary goal of the AAAD is to develop a network of services to assist residents achieve the highest possible level of independence, and works through an Advisory Council and the SWTDD Executive Committee to develop a plan of action to be implemented in its planning and service area. |
| Southwest Virginia Legal Aid Services | Non-profit law firm that provides free civil legal services to low-income families in southwestern Virginia with offices in Marion, Castlewood, and Christianburg. |