| Southern Illinois CIL | Southern Illinois Center for Independent Living is dedicated to the belief that persons with disabilities have the right and responsibility to make choices, to control the direction of their lives, and to participate fully and equally in their communities. |
| Southern Indiana Center for Independent Living (SICIL) | |
| Southern Maine Agency on Aging | Improve the quality of life for older adults, adults with disabilities, and the people who care for them. |
| Southern Maryland CIL (SMCIL) | Supporting people living with disabilities to lead self-directed independent lives. |
| Southern MN Enterprises and Services Center for Independent Living – Mankato | Provide an array of services that assist individuals with disabilities to live independently, pursue meaningul goals, and enjoy the same opportunities and choices as all persons. |
| Southern MN Enterprises and Services Center for Independent Living – New Ulm | Provide an array of services that assist individuals with disabilities to live independently, pursue meaningul goals, and enjoy the same opportunities and choices as all persons. |
| Southern MN Enterprises and Services Center for Independent Living – Waseca | Provide an array of services that assist individuals with disabilities to live independently, pursue meaningul goals, and enjoy the same opportunities and choices as all persons. |
| Southern Nevada Center for independent Living | Committed to “Removing Barriers Preventing Independent Living” by providing services designed to empower people with disabilities |
| Southern Nevada Center for independent Living – North Las Vegas | Committed to “Removing Barriers Preventing Independent Living” by providing services designed to empower people with disabilities |
| Southern Oklahoma Development Association AAA | Providing for a comprehensive and coordinated continuum of services and opportunities so older people can live dignified, productive and independent lives. |